RECRUITINGPhase 2INTERVENTIONAL

A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer

A Scalable Cruciferous Vegetable Intervention to Reduce Bladder Cancer Recurrence and Progression

About This Trial

This phase II trial is being done to develop and test a healthy eating program to reduce cancer recurrence (cancer that has come back after a period of improvement) and/or progression (cancer that is growing, spreading, or getting worse) in patients with non-muscle invasive bladder cancer (NMIBC). Researchers want to better understand how incorporating more cruciferous vegetables in the diet may reduce the risk of cancer recurrence or progression in men and women who were diagnosed with early-stage bladder cancer and compare whether extending the program can further improve bladder cancer outcomes. POW-R Health is a behavioral dietary intervention designed to modestly increase cruciferous vegetable (cruciferae) intake in patients. Cruciferous vegetables, such as cabbage, kale and broccoli, arugula, contain phytochemicals known as isothiocyanates (ITCs). Dietary ITCs exert potent anticancer activities against bladder cancer and can be rapidly metabolized, delivered to the bladder, and concentrated in the urine. Participating in the healthy eating program may reduce bladder cancer recurrence or progression in NMIBC survivors.

Who May Be Eligible (Plain English)

Who May Qualify: - English speaking - Diagnosed with stage Tis, Ta, or T1 bladder cancer - Age 18 years old or older (no upper limit) - Resides in New York State - Cancer not reported by a lab, nursing home, or death certificate/autopsy only - Did not receive a partial or radical cystectomy - Does not have other cancer diagnosis within 12 month of bladder cancer diagnosis nor under active treatment for any other cancers Who Should NOT Join This Trial: - Participants who had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier - Adults unable to consent - Adults unable to complete study measures in English - Individuals who are not yet adults (infants, children, teenagers) - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements - Unwilling or unable to follow protocol requirements - The following special populations ae excluded from this study: - Cognitively impaired adults/adults with impaired decision-making capacity - Individuals who are not yet adults (infants, children, teenagers) - Pregnant women - Prisoners Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * English speaking * Diagnosed with stage Tis, Ta, or T1 bladder cancer * Age 18 years old or older (no upper limit) * Resides in New York State * Cancer not reported by a lab, nursing home, or death certificate/autopsy only * Did not receive a partial or radical cystectomy * Does not have other cancer diagnosis within 12 month of bladder cancer diagnosis nor under active treatment for any other cancers Exclusion Criteria: * Participants who had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier * Adults unable to consent * Adults unable to complete study measures in English * Individuals who are not yet adults (infants, children, teenagers) * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Unwilling or unable to follow protocol requirements * The following special populations ae excluded from this study: * Cognitively impaired adults/adults with impaired decision-making capacity * Individuals who are not yet adults (infants, children, teenagers) * Pregnant women * Prisoners

Treatments Being Tested

BEHAVIORAL

Behavioral Dietary Intervention

Participate in POW-R Health Only/Core program

BEHAVIORAL

Telephone- Based Intervention

Receive live phone calls

Locations (1)

Roswell Park Comprehensive Cancer Center

Buffalo, New York, United States