Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis

Who May Qualify: - age \>18 years - History of MASLD, with liver fat content \> 5% - Normal kidney function - Stable medication for at least 1 month for diabetes mellitus if any - Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits Who Should NOT Join This Trial: - Age \< 18 years - Inaccurate 24-hour urine collections - Liver fat content \<5% - Liver cirrhosis - Evidence of other chronic liver disease, viral hepatitis - history of alcoholism within 2 years of enrollment - Contra-indication to Magnetic Resonance Imaging - Chronic kidney disease with estimated Glomerular Filtration rate \< 60 ml/min/1.73m2 - Type 1 Diabetes Mellitus or treatment with insulin - Uncontrolled diabetes - Pregnancy, lactation or intention to be - Uncontrolled hypertension - Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, chronic NSAID - History of gastric or intestinal surgery or resection that could potentially alter oxalate absorption - Chronic fat malabsorption - Use of immunosuppressive medications - Known immuno-compromised status - Active malignancy or treatment for malignanacy within the last 12 months Always talk to your doctor about whether this trial is right for you.