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RECRUITINGOBSERVATIONAL

MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B

Retrospective and Prospective Multi-center Clinical Study of Magnetic Resonance Elastography in Evaluating Hepatic Fibrosis in Chronic Viral Hepatitis B

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

How to construct a non-invasive, accurate, and convenient method to evaluate the severity of liver fibrosis (LF) is an important general problem in the management of patients with chronic hepatitis B (CHB). We plan to investigate the ability of magnetic resonance elastography (MRE) to grade fibrosis in chronic hepatitis B and apply to clinical longitudinal follow-up.

Who May Be Eligible (Plain English)

Who May Qualify: - Age ≥ 18 years old - Confirmed CHB (laboratory, imaging and clinical tests) - MRE within 6 months before and after liver biopsy - Treatment-naïve - Child-Pugh Grade A (\<7 points) - Written willing to sign a consent form in prospective follow-up cohort Who Should NOT Join This Trial: - Patients with liver malignant tumor - Chronic hepatitis due to other causes (such as alcoholic hepatitis) - CHB combined with hepatitis C, hepatitis D, or HIV - Patients with biliary tract diseases - Contraindications of MRE examination, MRE failure - Poor pathological effect Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age ≥ 18 years old * Confirmed CHB (laboratory, imaging and clinical tests) * MRE within 6 months before and after liver biopsy * Treatment-naïve * Child-Pugh Grade A (\<7 points) * Written informed consent in prospective follow-up cohort Exclusion Criteria: * Patients with liver malignant tumor * Chronic hepatitis due to other causes (such as alcoholic hepatitis) * CHB combined with hepatitis C, hepatitis D, or HIV * Patients with biliary tract diseases * Contraindications of MRE examination, MRE failure * Poor pathological effect

Treatments Being Tested

DEVICE

MRE

All imaging studies were performed by using a 1.5T/3.0-T MRI system

DEVICE

Liver biopsy

Liver biopsy are performed by well-trained pathologists in accordance with standard operating procedures.

Locations (1)

Shengjing Hospital
Shenyang, Liaoning, China