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RECRUITINGOBSERVATIONAL

Sphingolipidomic Profile in Anorexia Nervosa

Evaluation of the Sphingolipidomic Profile in Women Suffering From Anorexia Nervosa: Relationship With Clinical-endocrine and Psychiatric Parameters

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

: The objective of this research project will be to determine the sphingolipidomic profile in a group of women (\> 18 years) affected by Anorexia Nervosa (AN), phenotypically characterized (restricting \[AN-R\] vs binge-eating purging \[AN-BP\]). Specific questionnaires will be administered for the definition of the severity of the eating disorder and depressive state (suicidality), to which will be added the evaluation of gonadal function (i.e., plasma levels of estradiol/progesterone and use of oral contraceptives). Based on the specific lipidomic profile, which the present research project hopes to characterize, it will be possible to appropriately modify the diet of rehabilitation programs and, in the future, improve the effectiveness of the treatment itself, especially in the long term.

Who May Be Eligible (Plain English)

Patients with Anorexia Nervosa: Who May Qualify: - Female sex - Age: 18 years or older - Diagnosis of Anorexia Nervosa in the acute phase - Hospitalized at the Division of Eating and Nutrition Disorders (END), San Giuseppe Hospital, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy Who Should NOT Join This Trial: - Absence of signed willing to sign a consent form Control group: Who May Qualify: - Female sex - Age: 18 years or older - BMI between 18.5 and 24.9 kg/m2 Who Should NOT Join This Trial: - Absence of signed willing to sign a consent form Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Patients with Anorexia Nervosa: Inclusion Criteria: * Female sex * Age: 18 years or older * Diagnosis of Anorexia Nervosa in the acute phase * Hospitalized at the Division of Eating and Nutrition Disorders (END), San Giuseppe Hospital, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy Exclusion Criteria: * Absence of signed Informed Consent Control group: Inclusion Criteria: * Female sex * Age: 18 years or older * BMI between 18.5 and 24.9 kg/m2 Exclusion Criteria: * Absence of signed Informed Consent

Treatments Being Tested

OTHER

Determination of sphingolipidomic profile

The plasma/serum levels of the following sphingolipids will be measured: ceramides and dihydroceramides from C16 to C24, including 2 unsaturated ones (C18:1 and C24:1), sphingomyelins (those from C16 to C24 and the one C24:1), sphingosine, sphinganine, sphingosine-1-phosphate and sphinganine-1-phosphate.

Locations (1)

Istituto Auxologico Italiano IRCCS, Site Piancavallo
Oggebbio, Verbania, Italy