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RECRUITINGINTERVENTIONAL

Surveillance of Pancreatic Health After Diabetes Diagnosis

A Randomised Trial to Evaluate the cfDNA Pancreatic Cancer Test (Avantect) in the Early Detection of Pancreatic Cancer in Patients With Newly Diagnosed Diabetes Mellitus

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this interventional study is to evaluate if the novel diagnostic blood test, called Avantect can early detect pancreatic cancer in patients diagnosed with type 2 diabetes within the last 6 months. Participants will: * attend 3 study visits over 12 months time * provide a blood sample at each study visit * complete an anxiety questionnaire at each visit.

Who May Be Eligible (Plain English)

Who May Qualify: - 50 - 84 years of age at the time of enrolment (within year of birth, not month of birth) - Haemoglobin A1c (HbA1c) ≥ 48 or 6.5% and/or confirmed type II DM diagnosed within the last 180 days (+20 days flexibility allowance) - Willing to provide up to 30 mL of blood for each study visit - Willing and eligible to undergo MRI scan (or CT scan if MRI is contraindicated) - Understands the study process and is willing to take part in the study and sign the willing to sign a consent form form Who Should NOT Join This Trial: - Prior type I or type II DM diagnosis \> 6 months - A history of pancreatic cancer, pancreatic neuroendocrine tumour (pNET) or Pancreatitis - Under investigation for pancreatic cancer / pancreatic cyst - Any known pancreatic surgery (not including ERCP), or other major surgery requiring anaesthesia within 3 months - Any invasive solid or haematological cancer in the past 3 years, including cancer recurrence after treatment in the last 3 years - Current chronic or acute oral or systemic steroid use within 3 months of initial HbA1c or diabetes diagnosis (estimate rather than accurate) - Blood transfusion within 1 month - Solid organ transplant recipient - Currently pregnant - Needing dialysis Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * 50 - 84 years of age at the time of enrolment (within year of birth, not month of birth) * Haemoglobin A1c (HbA1c) ≥ 48 or 6.5% and/or confirmed type II DM diagnosed within the last 180 days (+20 days flexibility allowance) * Willing to provide up to 30 mL of blood for each study visit * Willing and eligible to undergo MRI scan (or CT scan if MRI is contraindicated) * Understands the study process and is willing to take part in the study and sign the informed consent form Exclusion Criteria: * Prior type I or type II DM diagnosis \> 6 months * A history of pancreatic cancer, pancreatic neuroendocrine tumour (pNET) or Pancreatitis * Under investigation for pancreatic cancer / pancreatic cyst * Any known pancreatic surgery (not including ERCP), or other major surgery requiring anaesthesia within 3 months * Any invasive solid or haematological cancer in the past 3 years, including cancer recurrence after treatment in the last 3 years * Current chronic or acute oral or systemic steroid use within 3 months of initial HbA1c or diabetes diagnosis (estimate rather than accurate) * Blood transfusion within 1 month * Solid organ transplant recipient * Currently pregnant * Needing dialysis

Treatments Being Tested

DEVICE

Avantect Pancreatic Cancer Test

Avantect test

Locations (20)

Ashfields Primary Care Centre
Sandbach, Cheshire, United Kingdom
Maidstone and Tunbridge Wells NHS Trust
Maidstone, Kent, United Kingdom
Balance Street Health Centre
Uttoxeter, Kent, United Kingdom
Forest Medical Group
Leicester, Leicester Forest East, United Kingdom
South Leicestershire Medical Group
Kibworth Beauchamp, Leicestershire, United Kingdom
Peel Croft Surgery
Burton-on-Trent, Staffordshire, United Kingdom
Kingswinford Medical Practice
Kingswinford, Staffordshire, United Kingdom
Park Medical Centre
Leek, Staffordshire, United Kingdom
Trinity Court Surgery
Stratford-upon-Avon, Staffordshire, United Kingdom
Brockwood Medical Practice
Brockham, Surrey, United Kingdom
Integrated Care Partnership/ The Old Cottage Hospital
Epsom, Surrey, United Kingdom
Warlingham Green Medical Practice
Warlingham, Surrey, United Kingdom
Ashton Medical Group
Ashton-under-Lyne, United Kingdom
Yardley Wood Health Centre
Birmingham, United Kingdom
Bournemouth Research Hub
Bournemouth, United Kingdom
Eastham Group Practice
Bromborough, United Kingdom
Willesden Medical Centre
London, United Kingdom
South Westminster Centre
London, United Kingdom
The Cuckoo Lane Practice
London, United Kingdom
Bodey Medical Centre
Manchester, United Kingdom