RECRUITINGPhase 1INTERVENTIONAL
Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case
A RCT Comparing the Effectiveness of a Combination Therapy of Lezra and Clomid Versus Lezra Alone for Inducing Ovulation in Women Diagnosed With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome
About This Trial
Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and letrozole combined.Mature follicles and endometrial thickness will be checked by transvaginal ultrasound and results will be recorded.
Who May Be Eligible (Plain English)
Who May Qualify:
- women of 20-40 years with a history of PCOS and resistant to CC
Who Should NOT Join This Trial:
- Premature ovarian insufficiency
- Husband has oligo azoospermia
- Hypothyroidism
- Hyperprolactinemia
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* women of 20-40 years with a history of PCOS and resistant to CC
Exclusion Criteria:
* Premature ovarian insufficiency
* Husband has oligo azoospermia
* Hypothyroidism
* Hyperprolactinemia
Treatments Being Tested
DRUG
Clomiphene Citrate and letrozole
clomiphene citrate 100mg once daily along with letrozole 5mg to one group and letrozole 5mg to second group
Locations (1)
HIT Hospital
Rawalpindi, Punjab Province, Pakistan