A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
A Phase 3, Randomized, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan Maintenance Treatment With or Without Bevacizumab Versus Standard of Care After Second-line Platinum-based Doublet Chemotherapy in Participants With Platinum-sensitive Recurrent Ovarian Cancer (TroFuse-022/ENGOT-ov84/GOG-3103)
About This Trial
The main goals of this study are to learn about the safety of sacituzumab tirumotecan with bevacizumab and if people tolerate it; and if people who take sacituzumab tirumotecan with or without bevacizumab live longer without the cancer getting worse than those who receive standard of care treatment.
Who May Be Eligible (Plain English)
Original Eligibility Criteria
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Treatments Being Tested
Sacituzumab tirumotecan
IV Infusion
Bevacizumab
IV Infusion
H1 receptor antagonist
Rescue medication taken per approved product label before sacituzumab tirumotecan
H2 receptor antagonist
Rescue medication taken per approved product label before sacituzumab tirumotecan
Acetaminophen (or equivalent)
Rescue medication taken per approved product label before sacituzumab tirumotecan
Dexamethasone (or equivalent)
Rescue medication taken per approved product label before sacituzumab tirumotecan
Steroid mouthwash (dexamethasone or equivalent)
Rescue medication taken orally 2-4 times daily