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RECRUITINGOBSERVATIONAL

The Development and Validation of MRI-AI-based Predictive Models for csPCa

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study retrospectively included patients who underwent prostate magnetic resonance imaging (MRI) and subsequent ultrasound-guided prostate biopsy at Peking University First Hospital from January 2019 to December 2023, and prospectively enrolls patients from January 2024 to December 2029. Clinical information such as age, PSA levels, PI-RADS scores, and digital rectal examination findings are collected. A well-performing artificial intelligence model is employed to measure prostate volume, transitional zone volume, and lesion volume using MRI images. Furthermore, prostate-specific antigen density (PSAD), transitional zone-based prostate-specific antigen density (TZ-PSAD) and lesion-based prostate-specific antigen density (lesion-PSAD) are calculated using prostate volume, transitional zone volume and lesion volume. Utilizing the aforementioned data, machine learning predictive models for clinically-significant prostate cancer (csPCa) are developed and validated.

Who May Be Eligible (Plain English)

Who May Qualify: - The interval between prostate MRI and biopsy within 3 months - Integrity of related data Who Should NOT Join This Trial: - PSA less than 50ng/ml - Any treatment for PCa prior to either MRI or biopsy, including radical prostatectomy, radiotherapy, chemotherapy, and endocrine therapy - Previous history of surgical treatment or 5α-reductase inhibitor therapy for benign prostatic hyperplasia - Subjects undergoing MRI with an indwelling urinary catheter or suprapubic catheter - Inadequate quality of MRI images Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * The interval between prostate MRI and biopsy within 3 months * Integrity of related data Exclusion Criteria: * PSA less than 50ng/ml * Any treatment for PCa prior to either MRI or biopsy, including radical prostatectomy, radiotherapy, chemotherapy, and endocrine therapy * Previous history of surgical treatment or 5α-reductase inhibitor therapy for benign prostatic hyperplasia * Subjects undergoing MRI with an indwelling urinary catheter or suprapubic catheter * Inadequate quality of MRI images

Locations (1)

Peking University First Hospital
Beijing, China