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RECRUITINGOBSERVATIONAL

Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis

Can Perfusion Index Indicate the Need of Vasopressor in ICU Patients with Sepsis and Septic Shock, Prospective Observational Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

In this thesis we will use the current state of knowledge that PI can provide a reliable information about the state of peripheral microcirculation during the state of sepsis and septic shock in ICU patients and that can interfere with the timing of starting vasopressor treatment in sepsis and septic shock

Who May Be Eligible (Plain English)

Who May Qualify: \- All ICU patients with clinically suspected sepsis and septic shock ( signs include fever hypotension oliguria and confusion combined with culture results showing infection .Septic shock is a subset of sepsis involves persistent hypotension (mean arterial pressure ≥ 65 mm Hg, and a serum lactate level \> 18 mg/dL \[2 mmol/L)not responding to fluid resuscitation ) . Who Should NOT Join This Trial: - Pregnant females - Patients on vasopressor or positive inotropic drugs - Patients with hypothermia (defined as central temperature \<35°C). - Patient with impairment of upper extremity circulation,(such as those who underwent radial artery harvesting for coronary artery bypass grafting or had suspected occlusion of the radial artery prior to surgery,) - Patients had undergone an operation that involved the large arteries of the aortic arch. - Patients with atherosclerosis . Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: \- All ICU patients with clinically suspected sepsis and septic shock ( signs include fever hypotension oliguria and confusion combined with culture results showing infection .Septic shock is a subset of sepsis involves persistent hypotension (mean arterial pressure ≥ 65 mm Hg, and a serum lactate level \> 18 mg/dL \[2 mmol/L)not responding to fluid resuscitation ) . Exclusion Criteria: * Pregnant females * Patients on vasopressor or positive inotropic drugs * Patients with hypothermia (defined as central temperature \<35°C). * Patient with impairment of upper extremity circulation,(such as those who underwent radial artery harvesting for coronary artery bypass grafting or had suspected occlusion of the radial artery prior to surgery,) * Patients had undergone an operation that involved the large arteries of the aortic arch. * Patients with atherosclerosis .

Treatments Being Tested

DRUG

Vasoconstrictor Agents

vasopressor agents will be started in patients with sepsis who will not improved using the resuscitation fluids

Locations (1)

faculty of medicine Ain Shams University
Cairo, Egypt