RECRUITINGINTERVENTIONAL
Circadian Rhythms in Human Adipose
Circadian Regulation of Human Adipose Tissue Metabolism
About This Trial
The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.
Who May Be Eligible (Plain English)
Who May Qualify:
- BMI 20-25 kg/m2 or 30-37 kg/m2
- For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females.
- sedentary
- females: non pregnant or breastfeeding
- ability to provide written willing to sign a consent form and follow study instructions
Who Should NOT Join This Trial:
- History of mediations that impact adipocyte/lipid metabolism
- smoking
- insomnia
- sleep apnea
- sleep medication use
- employment in night or shift work
- extreme chronotypes
- Allergy to lidocaine
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* BMI 20-25 kg/m2 or 30-37 kg/m2
* For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females.
* sedentary
* females: non pregnant or breastfeeding
* ability to provide written informed consent and follow study instructions
Exclusion Criteria:
* History of mediations that impact adipocyte/lipid metabolism
* smoking
* insomnia
* sleep apnea
* sleep medication use
* employment in night or shift work
* extreme chronotypes
* Allergy to lidocaine
Treatments Being Tested
OTHER
Continuous Feeding
Participants will receive 24-hour continuous feeds through an NG tube
OTHER
Intermittent feeding
Participants will receive 3 boluses of feeding per day at regular meal times through an NG tube to mimic normal meals.
Locations (1)
Mayo Clinic
Rochester, Minnesota, United States