RECRUITINGPhase 4INTERVENTIONAL
Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)
About This Trial
The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP). The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 18 years old diagnosed with severe CAP. The main question is whether there is a difference in all cause mortality within thirty days. Participants will be randomized to receive treatment with either hydrocortisone or prednisolone.
Who May Be Eligible (Plain English)
Who May Qualify:
- Age \> 18 years
- Diagnosis of severe CAP for who the physician in charge decides for corticosteroid therapy for severe CAP.
Who Should NOT Join This Trial:
- Admitted \>24 h
- Pregnant or breastfeeding women
- Active tuberculosis or fungal infection
- Pneumonia caused by influenza
- Intolerance to either study drug
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Age \> 18 years
* Diagnosis of severe CAP for who the physician in charge decides for corticosteroid therapy for severe CAP.
Exclusion Criteria:
* Admitted \>24 h
* Pregnant or breastfeeding women
* Active tuberculosis or fungal infection
* Pneumonia caused by influenza
* Intolerance to either study drug
Treatments Being Tested
DRUG
Methylprednisolone (drug)
ATC code: H02AB06. Can be changed to Prednisolone 50 mg orally.
DRUG
hydrocortisone
ATC-code: H02AB09. Can be changed to 50 mg x 4 daily orally if appropriate.
Locations (14)
Bornholm Hospital
Rønne, Bornholm, Denmark
Amager Hospital
Copenhagen, Copenhagen City, Denmark
Bispebjerg Hospital
Copenhagen, Copenhagen City, Denmark
Frederiksberg Hospital
Frederiksberg, Copenhagen City, Denmark
Gentofte Hospital
Hellerup, Copenhagen City, Denmark
Herlev Hospital
Herlev, Copnhagen Surroundings, Denmark
Hvidovre Hospital
Hvidovre, Copnhagen Surroundings, Denmark
Nordsjællands Hospital
Hillerød, North Zealand, Denmark
Holbæk Sygehus
Holbæk, Region Sjælland, Denmark
University Hospital of Region Zealand, Køge
Køge, Region Sjælland, Denmark
Næstved Sygehus
Næstved, Region Sjælland, Denmark
Ringsted Sygehus
Ringsted, Region Sjælland, Denmark
University Hospital of Region Zealand, Roskilde
Roskilde, Region Sjælland, Denmark
Slagelse Sygehus
Slagelse, Region Sjælland, Denmark