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RECRUITINGPhase 3INTERVENTIONAL

Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

Evaluating the Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines in the Emergency Department

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.

Who May Be Eligible (Plain English)

Who May Qualify: - Age ≥ 18 years or older - Able to provide willing to sign a consent form - English speaking - Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, who experience headaches with typical migraine features (e.g at least 2-3 of the following: recurrent, unilateral, pounding or throbbing in nature, associated with nausea), AND with a clinical exclusion of migraine mimics Who Should NOT Join This Trial: - Pregnancy defined as a positive urine HCG - Allergy or sensitivity to study drug - Stated history of renal insufficiency - Documented history of myasthenia gravis - Consumption of study drug within 48 hours prior to enrollment - Previously enrolled in this trial during a different patient encounter Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age ≥ 18 years or older * Able to provide informed consent * English speaking * Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, who experience headaches with typical migraine features (e.g at least 2-3 of the following: recurrent, unilateral, pounding or throbbing in nature, associated with nausea), AND with a clinical exclusion of migraine mimics Exclusion Criteria: * Pregnancy defined as a positive urine HCG * Allergy or sensitivity to study drug * Stated history of renal insufficiency * Documented history of myasthenia gravis * Consumption of study drug within 48 hours prior to enrollment * Previously enrolled in this trial during a different patient encounter

Treatments Being Tested

DRUG

Magnesium

Prochlorperazine 10 mg administered as an intravenous push over 2 minutes followed by magnesium 2 g administered as an intravenous bolus over a period of 20 minutes

DRUG

Placebo

Prochlorperazine 10 mg administered as an intravenous push over 2 minutes followed by placebo (normal saline)

Locations (1)

Advocate Christ Medical Center Emergency Department
Oak Lawn, Illinois, United States