A Pilot Study of Synbiotics in Adults With Depressive Symptoms

Who May Qualify: - Individuals aged 18 or above - Patient Health Questionnaire-9 (PHQ-9) score between 5 to 14 - Literate and can complete the self-report questionnaires - Able to understand the consent and sign the willing to sign a consent form form Who Should NOT Join This Trial: - Current diagnosis of substance abuse or dependence; - A current or past history of bipolar disorder, manic or hypomanic episodes, schizophrenia, personality disorder, posttraumatic stress disorder (PTSD), intellectual disability, neurodegenerative disorders (e. g, Parkinson's disease) or organic mental disorder - Requiring immediate psychiatric care (e. g, imminently suicidal subjects) or have attempted suicide in the past 3 months - Use of antipsychotics, antidepressants or sedatives, unless on a stable dose in the last 4 weeks - History of severe organ failure, renal failure on dialysis, HIV infection - Active malignancy within 5 years - History of major surgery on the gastrointestinal tract, except cholecystectomy and appendectomy in the past 5 years - Night shift work - History of antibiotic use within 4 weeks - History of allergy to probiotics or lactose leading to a severe allergic reaction - Known pregnancy or lactating Always talk to your doctor about whether this trial is right for you.