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RECRUITINGOBSERVATIONAL

Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF) The main questions this study aims to answer are: 1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease) 2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)

Who May Be Eligible (Plain English)

Who May Qualify: 1. Age 18 years and over 2. Primary presentation with symptoms related to atrial fibrillation 3. Atrial fibrillation with a ventricular rate \>100 bpm on a 12-lead electrocardiogram 4. Able to provide willing to sign a consent form Exclusion Criteria 1. Previous myocardial infarction 2. Previous coronary revascularisation procedure 3. Patients in renal failure (eGFR \<30ml/min/1.73m2) or major allergy to contrast media 4. Pregnancy or breast feeding 5. Deemed unsuitable for participation in the study by the attending clinician 6. Previous enrolment in the trial Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Age 18 years and over 2. Primary presentation with symptoms related to atrial fibrillation 3. Atrial fibrillation with a ventricular rate \>100 bpm on a 12-lead electrocardiogram 4. Able to provide informed consent Exclusion Criteria 1. Previous myocardial infarction 2. Previous coronary revascularisation procedure 3. Patients in renal failure (eGFR \<30ml/min/1.73m2) or major allergy to contrast media 4. Pregnancy or breast feeding 5. Deemed unsuitable for participation in the study by the attending clinician 6. Previous enrolment in the trial

Treatments Being Tested

DIAGNOSTIC_TEST

CT coronary angiography

To assess the presence of obstructive coronary artery disease, participants will either have coronary angiography as part of their routine care or they will return for a research CT scan of their heart (CT Coronary Angiogram)

Locations (1)

Royal Infirmary of Edinburgh
Edinburgh, East of England, United Kingdom