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RECRUITINGPhase 3INTERVENTIONAL

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The main purpose of this study is to see how orforglipron, compared with placebo, helps reduce body weight in participants with obesity or with overweight and at least one other related health condition (excluding type 2 diabetes). This trial is part of the master protocol study J2A-MC-GZPO (NCT06993792). Participation in the study will last about 18 months.

Who May Be Eligible (Plain English)

Who May Qualify: - Have body mass index (BMI) ≥30 kilograms per square meter (kg/m2) or BMI ≥25.0 kg/m2 and at least 1 of the following weight-related comorbidities at screening: - hypertension - dyslipidemia - obstructive sleep apnea, or - cardiovascular disease - Have a history of at least one unsuccessful dietary effort to lose body weight Who Should NOT Join This Trial: - Have type 1 diabetes, type 2 diabetes, or any other types of diabetes - Have an unstable body weight within 90 days prior to screening - Have New York Heart Association functional classification IV congestive heart failure or an acute cardiovascular condition within 90 days prior to screening - Have acute or chronic hepatitis or pancreatitis - Are taking other medications or alternative remedies to manage weight loss Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Have body mass index (BMI) ≥30 kilograms per square meter (kg/m2) or BMI ≥25.0 kg/m2 and at least 1 of the following weight-related comorbidities at screening: * hypertension * dyslipidemia * obstructive sleep apnea, or * cardiovascular disease * Have a history of at least one unsuccessful dietary effort to lose body weight Exclusion Criteria: * Have type 1 diabetes, type 2 diabetes, or any other types of diabetes * Have an unstable body weight within 90 days prior to screening * Have New York Heart Association functional classification IV congestive heart failure or an acute cardiovascular condition within 90 days prior to screening * Have acute or chronic hepatitis or pancreatitis * Are taking other medications or alternative remedies to manage weight loss

Treatments Being Tested

DRUG

Orforglipron

Administered orally

DRUG

Placebo

Administered orally

Locations (20)

Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, United States
Novak Clinical Research - Tucson - North La Cholla Boulevard
Tucson, Arizona, United States
Norcal Endocrinology & Internal Medicine
San Ramon, California, United States
Southern California Clinical Research
Santa Ana, California, United States
Care Access - Thousand Oaks
Thousand Oaks, California, United States
Accel Research Sites - DeLand Clinical Research Unit
DeLand, Florida, United States
Innovation Medical Research Center - Fort Lauderdale
Fort Lauderdale, Florida, United States
Indago Research & Health Center, Inc
Hialeah, Florida, United States
Encore Medical Research
Hollywood, Florida, United States
West Orange Endocrinology P.A.
Ocoee, Florida, United States
Care Access - Tampa
Tampa, Florida, United States
Conquest Research
Winter Park, Florida, United States
Accel Research Sites - NeuroStudies Clinical Research Unit
Decatur, Georgia, United States
Care Access - Decatur
Decatur, Georgia, United States
Javara - Privia Medical Group Georgia - Savannah
Savannah, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Solaris Clinical Research
Meridian, Idaho, United States
Care Access - New Iberia
New Iberia, Louisiana, United States
Endocrine and Metabolic Consultants
Rockville, Maryland, United States
Javara - Privia Medical Group - Silver Spring
Silver Spring, Maryland, United States