Multifactorial Strategies for the Prevention of the Risks of Ulceration in Patients Affected by Diabetic Foot (DARE-DiaFoot)

Inclusion Criteria for population 1: - Male and female patients aged between 18 and 75 years. - Diabetes mellitus type-2 patients with mild to moderate risk of ulceration at the foot (grade 2). Inclusion Criteria for population 2: - Male and female patients aged between 18 and 75 years. - Patients with diabetes mellitus type-2 and diabetic foot with an history of ulcerative lesions (grade 3), healed for at least 6 months. Exclusion Criteria for population 1: - History or evidence of ulcers at the foot - Infections in progress, ongoing neoplasms - Immunosuppressive therapies, and cortisone-based therapy - Pregnancy and lactation - Inability to provide willing to sign a consent form Exclusion Criteria for population 2: - Infections in progress, ongoing neoplasms - Immunosuppressive therapies, and cortisone-based therapy - Pregnancy and lactation - Inability to provide willing to sign a consent form Always talk to your doctor about whether this trial is right for you.