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RECRUITINGOBSERVATIONAL

Intestinal Permeability in Children With Autism Spectrum Disorder

Breaking Barriers: A Clinical Experimental Study of Intestinal Permeability in Children With Autism Spectrum Disorder

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

In recent years, increasing attention has been directed toward the role of the gut-brain axis in the pathogenesis of neurodevelopmental disorders, particularly Autism Spectrum Disorder (ASD). Among the multiple contributing factors, the integrity of the intestinal barrier appears to play a crucial role. Enhanced paracellular permeability ("leaky gut") may allow luminal antigens and microbial metabolites to translocate into the systemic circulation, triggering inflammatory responses that could impact neuropsychological functioning. Several studies suggest that, although intestinal permeability is not universally altered in all individuals with ASD, there exists a subset characterized by selective epithelial dysfunction, especially associated with repetitive and stereotyped behaviors. This project aims to investigate, through a controlled sibling-based design, whether intestinal permeability indices are significantly altered in children with ASD and whether such alterations are specifically correlated with behavioral domains assessed through the ADOS instrument.

Who May Be Eligible (Plain English)

* Children with a clinical diagnosis of ASD according to DSM-IV, confirmed by ADOS-G. - Consumption of a gluten-containing diet. - Negative celiac disease serology (EMA and anti-TG2 IgA antibodies). - Absence of IgE- or non-IgE-mediated food allergies. Who Should NOT Join This Trial: - Known neurological disorders. - Major congenital anomalies. - Severe head trauma. - Chronic gastrointestinal diseases. - Special diets (e.g., gluten-free or gluten/casein-free). - Antibiotic or probiotic/prebiotic intake in the previous 4 weeks. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
* Children with a clinical diagnosis of ASD according to DSM-IV, confirmed by ADOS-G. * Consumption of a gluten-containing diet. * Negative celiac disease serology (EMA and anti-TG2 IgA antibodies). * Absence of IgE- or non-IgE-mediated food allergies. Exclusion Criteria: * Known neurological disorders. * Major congenital anomalies. * Severe head trauma. * Chronic gastrointestinal diseases. * Special diets (e.g., gluten-free or gluten/casein-free). * Antibiotic or probiotic/prebiotic intake in the previous 4 weeks.

Locations (1)

University Of Bari Aldo Moro
Bari, BA, Italy