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RECRUITINGINTERVENTIONAL

Exercise in Hereditary ATTR (ATTRv) Amyloidosis

Effects of a 12-week Exercise Intervention on Physical and Mental Health in Hereditary ATTR (ATTRv) Amyloidosis

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study aims to explore the effects of a 12-week exercise intervention on the physical and mental health of people living with Hereditary ATTR (ATTRv) Amyloidosis, a rare genetic disease caused by mutations in the transthyretin gene, leading to the deposition of amyloid fibrils in nerves and organs.

Who May Be Eligible (Plain English)

Who May Qualify: - ATTRv Amyloidosis patients living in Portugal; - Disease stage 1 or 2; - No medical contraindication for exercising; - Ability to provide willing to sign a consent form. Who Should NOT Join This Trial: \- Having undergone a liver transplant in the past 6 months. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * ATTRv Amyloidosis patients living in Portugal; * Disease stage 1 or 2; * No medical contraindication for exercising; * Ability to provide informed consent. Exclusion Criteria: \- Having undergone a liver transplant in the past 6 months.

Treatments Being Tested

OTHER

Exercise

The exercise sessions will have a frequency of 3 times a week and a duration of 60 minutes per session. Exercise intensity will be gradually increased throughout the program and will be monitored every session using Borg's Rated Perceived Exertion scale, aiming at levels of 12-13 ("fairly light to somewhat hard"). The program will be mainly composed of cardiorespiratory exercises and resistance exercises. It will also comprise flexibility exercises to improve joint range of motion and neuromotor exercises involving motor skills (balance, agility, coordination, gait...), proprioceptive training and multifaceted activities (tai ji, yoga...).

Locations (1)

University of Maia
Maia, Porto District, Portugal