RECRUITINGINTERVENTIONAL
Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):
About This Trial
A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).
Who May Be Eligible (Plain English)
Who May Qualify:
1. willing to sign a consent form
2. Age 18-85 years
3. High burden paroxysmal AF (≥1%)
4. Moderate-severe OSA (AHI ≥ 15)
5. Implanted device with atrial diagnostics
6. Enrolled in remote monitoring
Who Should NOT Join This Trial:
1. AF ablation \<6 months
2. Valvular abnormalities
3. Excessive daytime sleepiness in safety-critical jobs
4. Plans for ablation during study
5. Non-CPAP OSA treatment
6. Recent device implantation (\<6 months)
7. Central sleep apnea
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
1. Informed consent
2. Age 18-85 years
3. High burden paroxysmal AF (≥1%)
4. Moderate-severe OSA (AHI ≥ 15)
5. Implanted device with atrial diagnostics
6. Enrolled in remote monitoring
Exclusion Criteria:
1. AF ablation \<6 months
2. Valvular abnormalities
3. Excessive daytime sleepiness in safety-critical jobs
4. Plans for ablation during study
5. Non-CPAP OSA treatment
6. Recent device implantation (\<6 months)
7. Central sleep apnea
Treatments Being Tested
DEVICE
CPAP
CPAP will be randomized 2 weeks on 2 weeks off for 12 weeks total
Locations (2)
Cleveland Clinic
Cleveland, Ohio, United States
University of Washington
Seattle, Washington, United States