Probenecid Administration for Alcohol Craving and Consumption

Who May Qualify: - • Male or female, ≥18 years. - women \>7 drinks/week; men \>14 drinks/week. - meet moderate to severe AUD score for DSM-5 criteria. - Breath Alcohol Content (BrAC)=0.00 at each visit. - in good health as confirmed by medical history, physical examination and lab tests. - willing to adhere to the study procedures. - understand willing to sign a consent form and questionnaires in English at an 8th grade level. Who Should NOT Join This Trial: - • Women who are breastfeeding or positive urine test for pregnancy. - clinically significant medical abnormalities: unstable hypertension, clinically significant abnormal EKG, bilirubin \>150% of the upper normal limit, ALT/AST \>300% the UNL, creatinine clearance ≤60 dl/min - meet DSM-5 criteria for a diagnosis of schizophrenia, bipolar disorder, or other psychoses - medications that reduce alcohol consumption (naltrexone, disulfiram). - use aspirin (salicylates may reduce effect of probenecid), penicillin, methotrexate (may increase concentration). - history of suicide attempts in the last three years. - current diagnosis of a moderate or severe cannabis use disorder as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline. - current diagnosis of another substance disorder at any severity, other than nicotine, as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline. - current use of medications that may interact with probenecid. - history of hypersensitivity to sulfa drugs. Always talk to your doctor about whether this trial is right for you.