GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices

Who May Qualify: - (a) A diagnosis of a spinal cord injury, brain stem stroke, or other neurological condition causing the participant to be non-ambulant and with bilateral upper limb motor impairment with no expectation of recovery that significantly or completely impairs the participant's ability to manually control a computer, smartphone or tablet with their hands. OR (b) A diagnosis of Amyotrophic Lateral Sclerosis (ALS) or other progressive neurological condition where the natural history of the disease is well understood and where there is tetraparesis and the expectation in the view of the participants treating neurologist that the disease will progress such that the participant will meet 1a within 1 year of recruitment. - Life expectancy ≥ 12 months. - Ability to communicate in English - Presence of a stable caregiver Who Should NOT Join This Trial: - Moderate to high risk for serious perioperative adverse events - Active implanted devices - Morbid obesity (Body Mass Index \> 40) - History of poorly controlled seizures or epilepsy - History of poorly controlled diabetes - Requires magnetic resonance imaging (MRI) for any ongoing medical conditions - Acquired or hereditary immunosuppression - Use of smoking tobacco or other tobacco products - Psychiatric or psychological disorder - Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy. - Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure Always talk to your doctor about whether this trial is right for you.