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RECRUITINGOBSERVATIONAL

PH-DyPred: A Multimodal Dynamic Risk Prediction Study in Pulmonary Hypertension

Research on Dynamic Risk Prediction for Patients With Pulmonary Hypertension Based on Multimodal Data Fusion: A Prospective Observational Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Pulmonary hypertension (PH) is a progressive cardiopulmonary disease characterized by elevated pulmonary artery pressure and vascular remodeling, which leads to right heart failure and increased mortality. Despite advances in diagnostics, risk stratification remains limited due to the disease's heterogeneity. This study aims to develop and validate a dynamic risk prediction model for PH by integrating multimodal data-including echocardiography, Cardiac MRI, PET-MR, ECG, biomarkers, and clinical features-using advanced machine learning algorithms. The study will establish a prospective cohort of PH patients to explore predictive markers, stratify prognosis, and provide a scientific basis for early warning and individualized management.

Who May Be Eligible (Plain English)

Who May Qualify: - Adults aged 18 years or older - Pulmonary artery systolic pressure (PASP) ≥35 mmHg as estimated by echocardiography - Provided written willing to sign a consent form Who Should NOT Join This Trial: - Severe hepatic or renal insufficiency - Malignancy under active treatment - Severe infection - Active autoimmune conditions (where your immune system attacks your own body) - Major surgery within the past 3 months - Pregnant or breastfeeding women - Severe psychiatric disorder impairing ability to comply with the study protocol Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Adults aged 18 years or older * Pulmonary artery systolic pressure (PASP) ≥35 mmHg as estimated by echocardiography * Provided written informed consent Exclusion Criteria: * Severe hepatic or renal insufficiency * Malignancy under active treatment * Severe infection * Active autoimmune disease * Major surgery within the past 3 months * Pregnant or breastfeeding women * Severe psychiatric disorder impairing ability to comply with the study protocol

Locations (1)

The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China