RECRUITINGOBSERVATIONAL

Validation of Energy Expenditure Measures Study

Energy Balance Within a Whole-Room Indirect Calorimeter and Its Relevance for Energy Expenditure Measures

About This Trial

The energy that the human body burns and the amount of food consumed determine a person's body weight. If food intake covers the amount of energy burned, body weight remains constant - a state known as energy balance. Achieving an energy balance is not easy in everyday life. This is reflected in the increasing number of people suffering from morbid obesity. To counteract this development, it is important to have a better understanding of how much food a person should eat. In this study, the investigators will investigate the amount of food needed to meet a person's energy needs and bring them into energy balance. Primary aims of the study are i) to technically and biologically validate two whole-room indirect calorimeters (WRICs) and ii) by using whole-room indirect calorimetry, to achieve a more accurate estimate of a person's emergy balance compared to common approximation formulas. Secondary study aims: 1. To investigate whether the transfer of a person into energy balance using WRIC has an influence on energy expenditure measures compared to the transfer into energy balance using the usual approximation formula. 2. To investigate whether the transfer of a person into energy balance using WRIC has an influence on activity-dependent energy expenditure measures compared to the transfer into energy balance using the usual approximation formula. 3. To investigate whether differences in energy expenditure during energy balance during moderate and strenuous physical activity influence food intake. 4. To investigate whether energy intake in relation to energy expenditure during energy balance is related to weight development

Who May Be Eligible (Plain English)

Who May Qualify: - Abilty to provide willing to sign a consent form - Written declaration of consent - Healthy study participants - Able to perform moderate physical exercise using a bike ergometer - Women: continuous contraception/fullicular phase of menstrual cycle Who Should NOT Join This Trial: - Weight change \> 5 kg or 5% of body weight in the last 3 months - Nicotine abuse, Alcohol/drug abuse - Strenuous physical activity in everyday life \> 1 h per day - Body mass index \< 18.5 kg/m² or ≥ 40 kg/m² - Chronic diseases with an impact on energy expenditure - Food allergy/intolerance, vegan diet - Circumstances that speak against the application of wearable accelerometers (e.g. silicone contact allergy) - Impaired fasting glucose, diabetes mellitus and prediabetes - Pregnancy/breastfeeding - Claustrophobia - Refusal to communicate incidental findings Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Abilty to provide informed consent * Written declaration of consent * Healthy study participants * Able to perform moderate physical exercise using a bike ergometer * Women: continuous contraception/fullicular phase of menstrual cycle Exclusion Criteria: * Weight change \> 5 kg or 5% of body weight in the last 3 months * Nicotine abuse, Alcohol/drug abuse * Strenuous physical activity in everyday life \> 1 h per day * Body mass index \< 18.5 kg/m² or ≥ 40 kg/m² * Chronic diseases with an impact on energy expenditure * Food allergy/intolerance, vegan diet * Circumstances that speak against the application of wearable accelerometers (e.g. silicone contact allergy) * Impaired fasting glucose, diabetes mellitus and prediabetes * Pregnancy/breastfeeding * Claustrophobia * Refusal to communicate incidental findings

Locations (1)

Department of Internal Medicine, Clinic for Endocrinology, Nephrology and Rheumatology, University of Leipzig

Leipzig, Saxony, Germany