Combination of COMBO Endoscopy Oropharyngeal Airway and HFNC Oxygenation in Sedated Gastrointestinal Endoscopy for Morbidly Obese Patients

Who May Qualify: - Age ≥ 18 years. - BMI ≥ 35 kg/m². - Patients undergoing gastroscopy or gastrointestinal endoscopy. - The estimated duration of the procedure does not exceed 45 minutes. - Patients have signed the willing to sign a consent form form. Who Should NOT Join This Trial: - Coagulation disorders or bleeding tendency (e.g., oral/nasal bleeding risk, mucosal injury, oropharyngeal obstruction) making oropharyngeal airway placement unsafe or unfeasible. - Active upper respiratory tract infection (oral, nasal, or pharyngeal), or fever (core temperature \>37.5°C). - Chronic obstructive pulmonary disease or other acute/chronic pulmonary diseases requiring long-term or intermittent oxygen therapy, or preoperative SpO₂ ≤ 92% on room air. - Severe organ dysfunction, including: Cardiac insufficiency (\<4 METs), Severe renal insufficiency (requiring dialysis), Diagnosed severe hepatic insufficiency, Increased intracranial pressure, ASA physical status ≥ IV. - Confirmed pregnancy or current breastfeeding. - Known allergy to sedatives (e.g., propofol) or medical adhesives. - Multiple traumatic injuries. - Current participation in another clinical trial. - Other conditions deemed unsuitable by the investigator. Always talk to your doctor about whether this trial is right for you.