RECRUITINGINTERVENTIONAL
Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment
BIA Monitoring and Exercise for the Prevention of Muscle Loss With Incretin Therapy (BICEP Study)
About This Trial
The goal of this study is to learn if a smartwatch that measures activity level and body composition, combined with exercise reminders, can safely improve strength and muscle mass in people who recently started or are planning to start treatment with incretin therapy (liraglutide, semaglutide, tirzepatide or retatrutide), also known as glucagon-like peptide 1 receptor agonist (GLP-1 RA) medications.
Who May Be Eligible (Plain English)
Inclusion Criteria
1. Age ≥ 18 years old at time of signing willing to sign a consent form
2. Started treatment with incretin therapy (liraglutide, semaglutide, tirzepatide, or retatrutide) within the past 2 months or planning to start this treatment
a. Potential participants switching GLP1-RA therapies due to inadequate response to a prior treatment will be eligible for enrollment
3. Able to provide willing to sign a consent form
Exclusion Criteria
1. Current pregnancy (positive urine hCG) or plans to become pregnant in the next 6 months
2. BMI \<25 kg/m2 at the time of screening
3. Unable to participate in a regular physical exercise program
4. Implanted pacemaker
5. Any factors that, in the opinion of the principal investigator, would interfere with the safe completion of the study
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria
1. Age ≥ 18 years old at time of signing informed consent
2. Started treatment with incretin therapy (liraglutide, semaglutide, tirzepatide, or retatrutide) within the past 2 months or planning to start this treatment
a. Potential participants switching GLP1-RA therapies due to inadequate response to a prior treatment will be eligible for enrollment
3. Able to provide informed consent
Exclusion Criteria
1. Current pregnancy (positive urine hCG) or plans to become pregnant in the next 6 months
2. BMI \<25 kg/m2 at the time of screening
3. Unable to participate in a regular physical exercise program
4. Implanted pacemaker
5. Any factors that, in the opinion of the principal investigator, would interfere with the safe completion of the study
Treatments Being Tested
DEVICE
Smartwatch activity and body composition monitor
Participants will be provided a smartwatch to monitor their exercise and body composition
BEHAVIORAL
General guidance on recommended exercise
Participants will receive general guidance on recommended exercise
Locations (1)
Diabetes Research Center
Boston, Massachusetts, United States