A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

Who May Qualify: - Have a body mass index (BMI) of: - ≥30 kilogram per square meter (kg/m2) OR - ≥27 kg/m2 with at least one of the following weight-related conditions: high blood pressure, abnormal levels of lipid, obstructive sleep apnea, heart disease - Have at least one unsuccessful attempt to lose weight by dieting Who Should NOT Join This Trial: - Have a self-reported change in body weight \>5 kg (11 pounds) within 90 days before screening - Have a prior or planned surgical treatment for obesity - Have type 1 diabetes or type 2 diabetes - Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) - Have had within the past 90 days before screening - acute myocardial infarction - cerebrovascular accident (stroke) - hospitalization for unstable angina, or - hospitalization due to congestive heart failure - Have New York Heart Association Functional Classification Class IV congestive heart failure - Have a history of chronic or acute pancreatitis - Have taken weight loss drugs, including over-the counter medications within 90 days prior to screening Always talk to your doctor about whether this trial is right for you.