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RECRUITINGINTERVENTIONAL

Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients

Virtual Reality Exposure Therapy in Patients With Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD). Participants are randomly assigned to one of the following interventions: a) exposure condition - the group with a standard CBT program enriched with exposure therapy in VR (VRET), b) control condition 1 - the group with a standard CBT program enriched with VR cognitive training aimed at cognitive flexibility or c) control condition 2 - standard CBT program without any additional VR intervention. The treatment effect will be evaluated using pre/post assessments, as well as monitoring adherence to exposure and response prevention assignments.

Who May Be Eligible (Plain English)

Who May Qualify: - Diagnosis of OCD (F42) using currently valid DSM-V and ICD-11 - Fluent in Czech Who Should NOT Join This Trial: - Any other psychiatric, neurological and serious somatic illness - Substance abuse - Psychotropic medication (e.g. benzodiazepines) except antidepressants, antipsychotic medication and hypnotics. - Contradictions to using a virtual reality (e.g., epilepsy, balance problems) - Pregnancy - Cardiostimulator and mental implants Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Diagnosis of OCD (F42) using currently valid DSM-V and ICD-11 * Fluent in Czech Exclusion Criteria: * Any other psychiatric, neurological and serious somatic illness * Substance abuse * Psychotropic medication (e.g. benzodiazepines) except antidepressants, antipsychotic medication and hypnotics. * Contradictions to using a virtual reality (e.g., epilepsy, balance problems) * Pregnancy * Cardiostimulator and mental implants

Treatments Being Tested

BEHAVIORAL

Exposure Therapy (Virtual Reality)

Virtual reality scenarios consists of exposures to OCD symptom provoking stimuli and response prevention (e.g. having dirty hands without washing them immediately) with the support of the therapist. The goal of VRET is sufficient reduction in anxiety and acceleration of progress in classical CBT.

BEHAVIORAL

Cognitive flexibility training

Participants play series of various cognitive games previously developed in NIMH aimed at cognitive flexibility. Games are presented using immersive VR (HTC vive headset). The set includes for instance Go/No-go paradigm with a shooting range addressing inhibitory control, Flies - hit a fly game addressing set-shifting and Castle game addressing spatial memory and reversal learning.

BEHAVIORAL

Standard CBT program without VR interventions

Standart CBT program (performed in all groups). The program involves regular group and individual psychotherapy sessions 5 days per 6 weeks.

Locations (1)

National Institute of Mental Health
Klecany, Czechia