Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

Who May Qualify: - Age 18-65 years - Trauma exposure - PTSD symptoms - Subclinical atherosclerotic CVD (e.g., coronary, cerebrovascular, or peripheral arterial plaque or calcifications on imaging), clinical atherosclerotic CVD (e.g., myocardial infarction or revascularization), or increased risk for atherosclerotic CVD (i.e., \>2 of hypertension, diabetes mellitus, hyperlipidemia, and active smoking) - Ability to understand and sign willing to sign a consent form Who Should NOT Join This Trial: - History of stroke, brain surgery, or seizure - Use of certain CVD medications (e.g., beta-blockers, high-intensity statins \[e.g., rosuvastatin 20/40 mg and atorvastatin 40/80 mg\], PCSK-9 inhibitors) - Psychiatric or cardiovascular medication change within 4 weeks (i.e., stable regimen is allowed) - Unstable blood pressure or cardiac arrhythmia - Currently in a supervised or graduated exercise program - Neurological or systemic inflammatory disease/current systemic anti-inflammatory therapy - Moderate/severe alcohol/substance use disorder - Current mania/psychosis - Weight \>300 lbs. - Claustrophobia - Pregnancy - Metal implants - Uncontrolled hyperglycemia (HgbA1c\>7.5%) - Subjects who have had significant radiation exposure as part of research (\>2 nuclear tests, computed tomography images, or fluoroscopic procedures) during the preceding 12-months Always talk to your doctor about whether this trial is right for you.