A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia

Who May Qualify: - History of fasting triglyceride levels of ≥500 milligrams per deciliter (mg/dL), based on medical history - Fasting triglyceride level ≥500 mg/dL at two separate visits during screening (at least 7 days apart) - Have a body mass index (BMI) within the range of 18.5 to 45.0 kilograms per square meter (kg/m2) (inclusive) Who Should NOT Join This Trial: - Have had a major atherosclerotic cardiovascular event within the past 3 months prior to screening - Have a history of acute pancreatitis within 12 months prior to screening - Have a known genetically confirmed diagnosis of Familial Chylomicronemia Syndrome - Have a history of or planned treatment involving any gene editing or gene therapy modalities, including but not limited to CRISPR-based, viral vector-mediated, or other genetic modification techniques - Have a history of chronic alcohol abuse within 3 years prior to screening Always talk to your doctor about whether this trial is right for you.