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RECRUITINGINTERVENTIONAL

Effect of HIIT on Post-Stroke Fatigue

Effect of High-Intensity Interval Training Intervention on Post-Stroke Fatigue in Chronic Stroke Survivors: A Pilot Randomized Clinical Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study aims to investigate the effect of high-intensity interval training (HIIT) on fatigue severity among individuals with chronic stroke. Participants will be randomly assigned to the HIIT group, the moderate-intensity continuous training (MICT) group, or the stretching group (active control). Each group will participate in supervised exercise sessions three times per week over a 12-week period, totaling 36 sessions. Outcome assessments will be conducted at baseline, mid-intervention (week 6), post-intervention (week 12), and follow-up (week 20). The primary outcome will be fatigue severity. Secondary outcomes will include inflammatory biomarkers and additional health-related indicators.

Who May Be Eligible (Plain English)

Who May Qualify: - Age of 40-80 years; - a history of ischemic stroke resulting in unilateral limb impairment 6-60 months prior to consent to participate in the pilot trial; - a stable medical condition; - a subjective feeling of fatigue, defined as a period of apparent fatigue, decreased energy, increased need for rest, or fatigue out of proportion to physical activity for at least 2 weeks during the past month; - ability to communicate with the investigators and lack of significant cognitive deficits; - able to walk for 10 meters with or without a walking aid. Who Should NOT Join This Trial: - An FSS score of \< 4 (20); - other neurological conditions; - other musculoskeletal comorbidities that would prevent safe participation in exercises; - a medical diagnosis of significant cardiovascular, pulmonary, or metabolic disease(s); - signs or symptoms indicative of significant cardiovascular, pulmonary, or metabolic disease(s) during the previous 3 months; - severe lower limb spasticity (Ashworth Scale score ≥ 3); - Botulinum toxin use in the affected lower limb within the past six months; - current or previous use of drugs intended to resolve post-stroke fatigue; - active engagement in other stroke rehabilitation trials. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion criteria: * Age of 40-80 years; * a history of ischemic stroke resulting in unilateral limb impairment 6-60 months prior to consent to participate in the pilot trial; * a stable medical condition; * a subjective feeling of fatigue, defined as a period of apparent fatigue, decreased energy, increased need for rest, or fatigue out of proportion to physical activity for at least 2 weeks during the past month; * ability to communicate with the investigators and lack of significant cognitive deficits; * able to walk for 10 meters with or without a walking aid. Exclusion criteria: * An FSS score of \< 4 (20); * other neurological conditions; * other musculoskeletal comorbidities that would prevent safe participation in exercises; * a medical diagnosis of significant cardiovascular, pulmonary, or metabolic disease(s); * signs or symptoms indicative of significant cardiovascular, pulmonary, or metabolic disease(s) during the previous 3 months; * severe lower limb spasticity (Ashworth Scale score ≥ 3); * Botulinum toxin use in the affected lower limb within the past six months; * current or previous use of drugs intended to resolve post-stroke fatigue; * active engagement in other stroke rehabilitation trials.

Treatments Being Tested

BEHAVIORAL

HIIT

The HIIT intervention will consist of a 3-minute warm-up, a 25-minute main exercise, and a 2-minute cool-down. The main exercise will include four 4-minute high-intensity intervals, each interspersed with a 3-minute low-intensity recovery period. Participants will attend three supervised sessions per week over a 12-week period.

BEHAVIORAL

MICT

The MICT intervention will include a 3-minute warm-up, 25 minutes of continuous exercise performed at a moderate intensity, and a 2-minute cool-down. Participants will attend three supervised sessions per week over a 12-week period.

BEHAVIORAL

stretching

The stretching intervention will consist of 30 minutes of whole-body stretching. Participants will attend three sessions per week over a 12-week period.

Locations (1)

The Hong Kong Polytechnic University
Kowloon, Hong Kong