RECRUITINGOBSERVATIONAL

Exercise and Carotid Artery Function in Metabolic Syndrome

Identifying Sex-specific Carotid Endothelial Dysfunction in Young Adults With Metabolic Syndrome

About This Trial

The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testing internal carotid artery function before and after a 30-minute bout of moderate intensity exercise. 48 young adults with and without metabolic syndrome will be enrolled and will be on study for approximately 5.5 hours over 4 study visits.

Who May Be Eligible (Plain English)

Inclusion Criteria (MetSyn cohort): - Waist circumference greater than 102 cm (males) or 82 cm (females) - Triglycerides over 150 mg/dL - HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females) - Blood pressure ≥130/85 mmHg - Fasting plasma glucose over 110 mg/dL Inclusion Criteria (Healthy cohort): \- meet age criteria Who Should NOT Join This Trial: - Current smoker, defined as more than 5 cigarettes over past 30 days - Current diagnosis or history of: - peripheral vascular disease - hepatic disease - renal disease - lung disease - gastrointestinal disorders/bleeding - hematologic disease - stroke - myocardial infarction - coronary heart disease - congestive heart failure - heart surgery - sleep apnea - autoimmune conditions (where your immune system attacks your own body)s - traumatic brain injury, concussion, stroke, or seizures - Asthma - Polycystic ovarian syndrome - Type II diabetes - Currently pregnant or breastfeeding - Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives - Hormonal contraceptive use, such as intrauterine device or hormonal implant use - Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography Exclusion Criteria (healthy controls only): - BMI greater than 25 kg/m2 - Blood pressure over 125/80 mmHg - Meeting any MetSyn criteria listed for MetSyn cohort Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria (MetSyn cohort): * Waist circumference greater than 102 cm (males) or 82 cm (females) * Triglycerides over 150 mg/dL * HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females) * Blood pressure ≥130/85 mmHg * Fasting plasma glucose over 110 mg/dL Inclusion Criteria (Healthy cohort): \- meet age criteria Exclusion Criteria: * Current smoker, defined as more than 5 cigarettes over past 30 days * Current diagnosis or history of: * peripheral vascular disease * hepatic disease * renal disease * lung disease * gastrointestinal disorders/bleeding * hematologic disease * stroke * myocardial infarction * coronary heart disease * congestive heart failure * heart surgery * sleep apnea * autoimmune diseases * traumatic brain injury, concussion, stroke, or seizures * Asthma * Polycystic ovarian syndrome * Type II diabetes * Currently pregnant or breastfeeding * Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives * Hormonal contraceptive use, such as intrauterine device or hormonal implant use * Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography Exclusion Criteria (healthy controls only): * BMI greater than 25 kg/m2 * Blood pressure over 125/80 mmHg * Meeting any MetSyn criteria listed for MetSyn cohort

Treatments Being Tested

BEHAVIORAL

exercise

30 minute bout of cycling

DIAGNOSTIC_TEST

Diagnostics

* Doppler Ultrasound used to non-invasively assess the diameter and blood flow going into an artery, the ICA in this study. * Indirect calorimeter in tandem with semi-recumbent bike used to assess O2 consumption * heart rate monitor

OTHER

Inhaled CO2-mixed air

Three gases of different composition are used to ensure that the proper PETCO2 administration desired for this study occurs in tandem with keeping inspired O2 content constant. This is achieved by used a 5% O2, 95% CO2 tank, a 5% O2, 95% N2 tank, and a 100% O2 tank. In tandem, the use of these three tanks allows for precise control of PETCO2 without a change in inspired O2.

Locations (1)

University of Wisconsin

Madison, Wisconsin, United States