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RECRUITINGOBSERVATIONAL

Using Liquid Biopsy Testing to Identify, Monitor, Predict Recurrence in Urothelial Carcinoma

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Application of Multi-Component Liquid Biopsy (ctDNA, utDNA, Exosomes, and Protein Biomarkers in Blood and Urine) for Auxiliary Diagnosis, Therapeutic Response Evaluation, and Recurrence Monitoring in Urothelial Carcinoma

Who May Be Eligible (Plain English)

Who May Qualify: - Suspected or diagnosed by tissue sample (biopsy-confirmed) urothelial carcinoma Who Should NOT Join This Trial: - History of or concurrent active malignancy other than urothelial carcinoma Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Suspected or histologically confirmed urothelial carcinoma Exclusion Criteria: * History of or concurrent active malignancy other than urothelial carcinoma

Treatments Being Tested

DIAGNOSTIC_TEST

Multi-Component Liquid Biopsy for Urothelial Carcinoma

This intervention is a non-invasive, multi-component liquid biopsy assay specifically designed for patients with urothelial carcinoma (including bladder cancer and upper tract urothelial carcinoma). It integrates multiple tumor-derived analytes from paired blood and urine samples: circulating cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) from peripheral blood plasma, urinary tumor DNA (utDNA)/cell-free DNA from urine, exosomal RNAs (e.g., miRNAs, lncRNAs) and proteins from urine-derived exosomes, and selected tumor-associated proteins. Serial sampling is performed at key clinical time points to enable longitudinal assessment: 1. Pre-diagnosis or baseline 2. During treatment 3. Post-treatment surveillance

Locations (1)

The second hospital of Tianjin Medical University
Tianjin, China