RECRUITINGOBSERVATIONAL
LRFN5 and OLFM4 in Methamphetamine-Induced Psychosis
Serum LRFN5 and OLFM4 Levels in Methamphetamine Use Disorder and Methamphetamine-Induced Psychotic Disorder: A Cross-Sectional Case-Control Study
About This Trial
This cross-sectional observational case-control study aimed to examined serum levels of leucine-rich repeat and fibronectin type III domain-containing protein 5 (LRFN5) and olfactomedin-4 (OLFM4) levels in methamphetamine use disorder (MUD), methamphetamine-induced psychotic disorder (MP), and healthy control (HC) groups. The study also aimed to assessed systemic inflammation using the Aggregate Index of Systemic Inflammation (AISI) and examined associations between biomarkers and clinical symptom severity, including Insight Assessment Scale (IAS) and Positive and Negative Syndrome Scale (PANSS) scores.
Who May Be Eligible (Plain English)
1. For Methamphetamine Use Disorder (MUD) Group:
\*Who May Qualify:
- Diagnosis of MUD according to DSM-5-TR
- Medication-free for at least one month prior to admission
- Age ≥ 18 years and \<65 years
- Provided willing to sign a consent form
For Methamphetamine Use Disorder (MUD) Group:
\*Who Should NOT Join This Trial:
• Hypertension
- Diabetes mellitus
- Chronic kidney disease
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Cardiac illness
- Severe neurological disorders
- Immunological or systemic illness
- Primary psychiatric disorders other than MUD
- Alcohol use disorder
2. For Methamphetamine-Induced Psychotic Disorder (MP) Group:
\*Who May Qualify:
- Diagnosis of MP according to DSM-5-TR
- Medication-free for at least one month prior to admission
- Age ≥ 18 years and \<65 years
- Provided willing to sign a consent form
For Methamphetamine-Induced Psychotic Disorder (MP) Group:
\*Who Should NOT Join This Trial:
- Hypertension
- Diabetes mellitus
- Chronic kidney disease
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Cardiac illness
- Severe neurological disorders
- Immunological or systemic illness
- Primary psychiatric disorders other than MP
- Alcohol use disorder
3. For Healthy Control Group:
\*Who May Qualify:
- No psychiatric diagnosis
- No systemic or immunological illness
- Medication-free for at least one month
- Age ≥ 18 years and \<65 years
- Provided willing to sign a consent form
For Healthy Control Group:
\*Who Should NOT Join This Trial:
• Hypertension
- Diabetes mellitus
- Chronic kidney disease
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Cardiac illness
- Severe neurological disorders
- Immunological or systemic illness
- Primary psychiatric disorders other than schizophrenia
- Alcohol/drug/substance use
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
1. For Methamphetamine Use Disorder (MUD) Group:
\*Inclusion Criteria:
* Diagnosis of MUD according to DSM-5-TR
* Medication-free for at least one month prior to admission
* Age ≥ 18 years and \<65 years
* Provided informed consent
For Methamphetamine Use Disorder (MUD) Group:
\*Exclusion Criteria:
• Hypertension
* Diabetes mellitus
* Chronic kidney disease
* Rheumatoid arthritis
* Systemic lupus erythematosus
* Cardiac illness
* Severe neurological disorders
* Immunological or systemic illness
* Primary psychiatric disorders other than MUD
* Alcohol use disorder
2. For Methamphetamine-Induced Psychotic Disorder (MP) Group:
\*Inclusion Criteria:
* Diagnosis of MP according to DSM-5-TR
* Medication-free for at least one month prior to admission
* Age ≥ 18 years and \<65 years
* Provided informed consent
For Methamphetamine-Induced Psychotic Disorder (MP) Group:
\*Exclusion Criteria:
* Hypertension
* Diabetes mellitus
* Chronic kidney disease
* Rheumatoid arthritis
* Systemic lupus erythematosus
* Cardiac illness
* Severe neurological disorders
* Immunological or systemic illness
* Primary psychiatric disorders other than MP
* Alcohol use disorder
3. For Healthy Control Group:
\*Inclusion Criteria:
* No psychiatric diagnosis
* No systemic or immunological illness
* Medication-free for at least one month
* Age ≥ 18 years and \<65 years
* Provided informed consent
For Healthy Control Group:
\*Exclusion Criteria:
• Hypertension
* Diabetes mellitus
* Chronic kidney disease
* Rheumatoid arthritis
* Systemic lupus erythematosus
* Cardiac illness
* Severe neurological disorders
* Immunological or systemic illness
* Primary psychiatric disorders other than schizophrenia
* Alcohol/drug/substance use
Locations (1)
Elazığ Mental Health and Diseases Hospital
Elâzığ, Elâzığ, Turkey (Türkiye)