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RECRUITINGOBSERVATIONAL

Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Who May Be Eligible (Plain English)

Who May Qualify: - age \> 18 years - Healthy subjects: no history of heart disease - Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40% - Left ventricular hypertrophy: wall thickness \>1.2cm - Coronary artery disease: \>50% coronary lesion or positive stress test Who Should NOT Join This Trial: - contraindication to MRI Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * age \> 18 years * Healthy subjects: no history of heart disease * Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40% * Left ventricular hypertrophy: wall thickness \>1.2cm * Coronary artery disease: \>50% coronary lesion or positive stress test Exclusion Criteria: * contraindication to MRI

Locations (1)

Johns Hopkins Medical Institutions
Baltimore, Maryland, United States