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RECRUITINGINTERVENTIONAL

Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

Radiotracer Imaging of Skeletal Muscle Perfusion in Patients With Peripheral Artery Disease

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in patients with peripheral artery disease (PAD) who are undergoing lower extremity revascularization procedures. We hypothesize that radiotracer imaging of the lower extremities will provide a sensitive non-invasive imaging tool for quantifying regional abnormalities in skeletal muscle perfusion and evaluating responses to medical treatment.

Who May Be Eligible (Plain English)

Inclusion Criteria for Patients with Peripheral Artery Disease: 1. At least 18 years of age 2. Evidence of significant obstructive disease for one or multiple lower extremity arteries, as identified by prior ABI, TBI, CT angiography, ultrasound, or MR imaging. Exclusion Criteria for Patients with Peripheral Artery Disease: 1. Unable to give willing to sign a consent form or follow-up 2. Pregnant or nursing 3. Under the age of 18 4. No history of peripheral artery disease Inclusion Criteria for Healthy Control Subjects: 1. At least 18 years of age 2. No evidence or prior diagnosis of peripheral artery disease based on chart review and standard vascular screening. Exclusion Criteria for Healthy Control Subjects: 1. Unable to give willing to sign a consent form of follow-up 2. Pregnant or nursing 3. Under the age of 18 4. History of peripheral artery disease Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria for Patients with Peripheral Artery Disease: 1. At least 18 years of age 2. Evidence of significant obstructive disease for one or multiple lower extremity arteries, as identified by prior ABI, TBI, CT angiography, ultrasound, or MR imaging. Exclusion Criteria for Patients with Peripheral Artery Disease: 1. Unable to give informed consent or follow-up 2. Pregnant or nursing 3. Under the age of 18 4. No history of peripheral artery disease Inclusion Criteria for Healthy Control Subjects: 1. At least 18 years of age 2. No evidence or prior diagnosis of peripheral artery disease based on chart review and standard vascular screening. Exclusion Criteria for Healthy Control Subjects: 1. Unable to give informed consent of follow-up 2. Pregnant or nursing 3. Under the age of 18 4. History of peripheral artery disease

Treatments Being Tested

DIAGNOSTIC_TEST

SPECT/CT perfusion imaging

Subjects will receive a standard clinical dose of a radionuclide for perfusion imaging of the lower extremities before and after revascularization procedures.

DIAGNOSTIC_TEST

PET/CT perfusion imaging

Subjects will receive a standard clinical dose of a radionuclide for perfusion imaging of the lower extremities before and after revascularization procedures.

Locations (1)

Nationwide Children's Hospital
Columbus, Ohio, United States