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RECRUITINGOBSERVATIONAL

French Registry for Monitoring Pregnancies for Multiple Sclerosis

French Registry for Monitoring Pregnancies and Children of Women With Multiple Sclerosis Within The Observatoire Français de la Sclérose en Plaque (OFSEP) Cohort

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The influence of pregnancy on the course of multiple sclerosis (MS) has long been a controversial topic. After the publication of the first large prospective study of pregnancy and MS in 1998, counselling of women with MS has radically changed and many patients have been able to fulfill their desire of motherhood. However, there are still some challenges for the neurologist, who has to face old unanswered questions or new issues, regarding the use of disease modifying drugs (DMDs) in this period of life, effects on the short and long term outcome of the mother (in terms of relapses and disability) and the child, role of breast-feeding and locoregional analgesia. To set up a national prospective pregnancy registry for patients with MS, nested within the Observatoire Français de la Sclérose en Plaque (OFSEP) cohort, owing to a better knowledge of interactions between MS and pregnancy-related issues (pregnancy itself, locoregional analgesia, breastfeeding, impact of using or stopping DMDs on women/children…)

Who May Be Eligible (Plain English)

Who May Qualify: - All groups of patients eligible to participate to the Observatoire Français de la Sclérose en Plaque (OFSEP), including : - Definite Multiple sclerosis (MS) according to McDonald criteria - Whatever the clinical course (single attack MS, relapsing-remitting MS, secondary progressive MS, primary progressive MS) - Radiologically Isolated Syndromes (RIS) (will be validated by the RIS expert group) - Clinically Isolated Syndromes (CIS) - Neuromyelitis optica (NMO) and NMO spectrum disorders (will be validated by the "Neuro-optico-myélite aiguë de Devic et des syndromes neurologiques apparentés" (NOMADMUS) expert group) - No age limit (patients under the age of 18 might be included, provided willing to sign a consent form is obtained from the parents) - Ongoing pregnancy: there will be no limit in the gestational age at inclusion. Women can be included at any time before delivery, but the gestational age at inclusion will be recorded and introduced in the analyses whenever pertinent. However, neurologists and patients will be encouraged to start the study as soon as pregnancy is diagnosed. - Able to give willing to sign a consent form - Able to read and/or understand French Who Should NOT Join This Trial: - None Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * All groups of patients eligible to participate to the Observatoire Français de la Sclérose en Plaque (OFSEP), including : * Definite Multiple sclerosis (MS) according to McDonald criteria * Whatever the clinical course (single attack MS, relapsing-remitting MS, secondary progressive MS, primary progressive MS) * Radiologically Isolated Syndromes (RIS) (will be validated by the RIS expert group) * Clinically Isolated Syndromes (CIS) * Neuromyelitis optica (NMO) and NMO spectrum disorders (will be validated by the "Neuro-optico-myélite aiguë de Devic et des syndromes neurologiques apparentés" (NOMADMUS) expert group) * No age limit (patients under the age of 18 might be included, provided informed consent is obtained from the parents) * Ongoing pregnancy: there will be no limit in the gestational age at inclusion. Women can be included at any time before delivery, but the gestational age at inclusion will be recorded and introduced in the analyses whenever pertinent. However, neurologists and patients will be encouraged to start the study as soon as pregnancy is diagnosed. * Able to give informed consent * Able to read and/or understand French Exclusion Criteria: * None

Treatments Being Tested

OTHER

No intervention

No intervention

Locations (20)

Chu D'Amiens
Amiens, France
Centre Hospitalier Annecy Genevois
Annecy, France
Centre Hospitalier d'Avignon
Avignon, France
Hopital Jean Minjoz
Besançon, France
Hopital Pellegrin
Bordeaux, France
Hôpital de Brive
Brive-la-Gaillarde, France
Hôpital Neurologique Pierre Wertheimer
Bron, France
Hopital Cote de Nacre
Caen, France
Centre hospitalier Métropole Savoie
Chambéry, France
Hopital Gabriel Montpied
Clermont-Ferrand, France
Hopital Henri Mondor
Créteil, France
Hopital Du Bocage
Dijon, France
Ch Epinal
Épinal, France
Hôpital Raymond Poincaré
Garches, France
Centre hospitalier Joséphine Baker Gonesse
Gonesse, France
Chu de Grenoble
Grenoble, France
Centre Hospitalier de Versailles Hôpital Andre Mignot
Le Chesnay, France
Hôpital St Vincent De Paul
Lille, France
Chru de Lille
Lille, France
Hopital Dupuytren
Limoges, France