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RECRUITINGINTERVENTIONAL

rTMS for Apathy Clinical Trial

Repetitive Transcranial Magnetic Stimulation for Apathy Clinical Trial (REACT)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in neurocognitive disorders and mild behavioural impairment in individuals receiving methylphenidate and individuals not receiving medication for apathy.

Who May Be Eligible (Plain English)

Who May Qualify: - mild or major neurocognitive disorder OR mild behavioural impairment - Apathy for at least 4 weeks - Stable dose of medication (\>4 weeks) that may affect cognition or behaviour - Care partner who spends at least 10 hours a week with the subject Who Should NOT Join This Trial: - Current major depressive episode - Agitation, delusions, hallucination - Medical contraindications to rTMS - Currently taking an amphetamine product - Central nervous system abnormalities, Tourette's syndrome, or motor tics - Current participation in another clinical trial Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * mild or major neurocognitive disorder OR mild behavioural impairment * Apathy for at least 4 weeks * Stable dose of medication (\>4 weeks) that may affect cognition or behaviour * Care partner who spends at least 10 hours a week with the subject Exclusion Criteria: * Current major depressive episode * Agitation, delusions, hallucination * Medical contraindications to rTMS * Currently taking an amphetamine product * Central nervous system abnormalities, Tourette's syndrome, or motor tics * Current participation in another clinical trial

Treatments Being Tested

DEVICE

rTMS

repetitive transcranial magnetic stimulation

DRUG

methylphenidate

methylphenidate

Locations (1)

Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada