Evaluation of BTV100 in Subjects With Dry Eye Disease

Who May Qualify: 1. 18 years of age or older (regardless of gender). 2. Provide written willing to sign a consent form. 3. Willing and able to follow instructions and be available for required study visits during the study. 4. Best Corrected Visual Acuity (BCVA) of 20/100 or better in both eyes. 5. Ongoing moderate to severe Dry Eye Disease (DED) supported by a previous clinical diagnosis or a self-reported history of subjective complaints for at least 6 months prior to the screening visit, and meet all the following criteria in at least one eye (the same eye) at Visit 1 and Visit 2: Who Should NOT Join This Trial: 1. Known hypersensitivity or contraindication to the study drug or its components. 2. Within 28 days prior to the screening visit (Visit 1), have taken or used: Topical ophthalmic, dermatologic or systemic calcineurin inhibitor (e.g. cyclosporine and tacrolimus), including Restasis® (cyclosporine) and Cequa® (cyclosporine) 3. Current use of contact lenses or anticipated use during the study. Always talk to your doctor about whether this trial is right for you.