Registry for Esophageal and Gastroesophageal Junction Cancer

Who May Qualify: - Newly diagnosed stage IV adenocarcinoma of the esophagus or GEJ with OMD at the time of diagnosis, defined as the following: - Retroperitoneal lymph nodes (e.g., para-aortal, intra-aorto-caval, parapancreatic, or mesenterial lymph node) - Liver - Lung - Extra-abdominal lymph nodes (e.g., supraclavicular or cervical lymph nodes) - Adrenal gland - Unilateral or bilateral ovarian metastases (in the absence of gross or microscopic peritoneal disease \[positive cytology\]) - Bone - ≤2 sites of disease (excluding the primary tumor and regional lymph nodes) - ≤3 tumors within each organ system - ≤5 metastases - All nonregional lymph nodes (including cervical, supraclavicular, and retroperitoneal nodal disease) are considered 1 discrete lesion - Satellite lesions in the primary esophageal malignancy, such as skipped esophageal primaries, are not considered metastatic sites - All sites of disease must be amenable to complete local therapy after systemic therapy, according to the treating physician. Treatment modalities include: - Surgery - Definitive chemoradiation - Stereotactic radiation - Ablation or similar techniques (e.g., irreversible electroporation) - Age ≥18 years Who Should NOT Join This Trial: - Presence of metastases, at the time of diagnosis, to the following: - Peritoneum, including positive peritoneal lavage (on the basis of baseline diagnostic laparoscopy to rule out gross disease and positive peritoneal lavage cytology; laparoscopy may be omitted for patients in whom all sites of disease are above the diaphragm) - Malignant pleural effusion - Brain metastases or leptomeningeal disease - Other sites not specifically noted must be reviewed and approved by the PIs - Any site of disease that is not amenable to definitive local therapy - Unfit for best systemic therapy - Metachronous OMD - Secondary primary cancer, with the exclusion of basal cell carcinoma of the skin - Pregnant, lactating, or intending to become pregnant ...See full criteria on ClinicalTrials.gov Always talk to your doctor about whether this trial is right for you.