A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*Case

Who May Qualify: - Participants have at the time of inclusion been referred to treatment for depression as a primary diagnosis in a psychiatric clinic - Participants should meet the diagnosis of chronic or treatment-resistant depression as follows: 1. Clinical major depression as measured by the M.I.N.I. diagnostic interview: duration minimum two years OR persistent after = 2 trials of antidepressants from different classes, in an adequate dosage and time period (= 4 weeks) OR moderate treatment resistance as measured on the MSM-scale, score \> 6 2. Minimum a score of 9 points on the Hamilton Rating Scale for Depression 6 (HAMD-6), corresponding to moderate to severe depression Who Should NOT Join This Trial: - Alcohol or substance abuse - Bipolar or psychotic disorder - Acute suicidal risk - Mental disability (estimated IQ \< 70) - Non-Danish speaker - Known to be pregnant at time of inclusion Psychiatric comorbidity is not an exclusion criteria, until the comorbid disorder is understood to be the primary psychiatric problem and as such the patient would be treated in a different care package, e.g., for Post-Traumatic Stress Disorder (The inclusion and exclusion criteria follow that of the mother study (clinicaltrial.gov ID NCT05833087)) Always talk to your doctor about whether this trial is right for you.