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RECRUITINGINTERVENTIONAL

Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease

Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell (ALL IN)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This is a single site nonrandomized pilot clinical trial of the feasibility, acceptability, and efficacy of a combination treatment involving digital Cogmed working memory skills training, social support components, and memory strategy training to improve adherence to Cogmed in youth with sickle cell disease ages 7-16 years.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Diagnosis of sickle cell disease (any genotype). 2. Between ages 7-16 years old. 3. Patients will only enter the treatment phase if they score \>1 SD below the normative mean on at least one standardized working memory assessment (i.e., Digit Span or Spatial Span subtests) or demonstrate a relative weakness in working memory (\>1 SD below the estimated IQ). Who Should NOT Join This Trial: 1. Motor, visual, or auditory impairment that prevents computer use. 2. Diagnosis of a mental health condition that precludes, or takes treatment precedence over, participation in the cognitive training. 3. History of photosensitive seizures. 4. Insufficient English fluency. 5. Recent initiation or dose adjustment of a stimulant medication to treat attention problems (\< 30 days). Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Diagnosis of sickle cell disease (any genotype). 2. Between ages 7-16 years old. 3. Patients will only enter the treatment phase if they score \>1 SD below the normative mean on at least one standardized working memory assessment (i.e., Digit Span or Spatial Span subtests) or demonstrate a relative weakness in working memory (\>1 SD below the estimated IQ). Exclusion Criteria: 1. Motor, visual, or auditory impairment that prevents computer use. 2. Diagnosis of a mental health condition that precludes, or takes treatment precedence over, participation in the cognitive training. 3. History of photosensitive seizures. 4. Insufficient English fluency. 5. Recent initiation or dose adjustment of a stimulant medication to treat attention problems (\< 30 days).

Treatments Being Tested

BEHAVIORAL

Cogmed+

Cogmed is a home-based, digital working memory training program compatible with tablet devices. The program, designed for children ages 7 and older, consists of engaging cognitive exercises that target skills involving visuospatial and verbal working memory. An essential component of Cogmed training involves assignment of an intervention "coach" who has access to detailed data on the user's training data. Families will have videoconference meetings once per week with an intervention coach to review progress, provide feedback and answer any questions that arise during treatment. In addition, participants' coaching calls will be supplemented with direct instruction on the use of memory strategies. Social support interventions will also be provided involving three primary approaches: (1) multi-family Cogmed Kickoff social events; (2) social incentives; and (3) peer navigator support.

Locations (1)

Children's National Hospital
Washington D.C., District of Columbia, United States