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RECRUITINGOBSERVATIONAL

Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients

Association Between Vasopressor Exposure Levels and 30-Day Mortality in Patients Receiving ECMO Support for Cardiogenic Shock: A Prospective Multicenter Cohort Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this observational study is to learn about the association between vasopressor exposure levels and outcomes in adults with cardiogenic shock receiving VA-ECMO. The main question it aims to answer is: Does reduced exposure to vasopressors lower the 30-day mortality in patients with cardiogenic shock when receiving ECMO support? Participants who are receiving ECMO support for cardiogenic shock as part of their regular medical care will have their data collected, including information about their vasopressor use and mortality outcomes, over the course of the study.

Who May Be Eligible (Plain English)

Who May Qualify: - Adults (≥18 years) with cardiogenic shock requiring VA-ECMO support. - First-time ECMO initiation. - Venoarterial ECMO (VA-ECMO) as the initial mode. Who Should NOT Join This Trial: - Age \<18 years. - Severe pulmonary hypertension. - Vasopressor use for non-shock indications (e.g., bleeding, post-cardiopulmonary bypass vasoplegia). - Severe missing data. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Adults (≥18 years) with cardiogenic shock requiring VA-ECMO support. * First-time ECMO initiation. * Venoarterial ECMO (VA-ECMO) as the initial mode. Exclusion Criteria: * Age \<18 years. * Severe pulmonary hypertension. * Vasopressor use for non-shock indications (e.g., bleeding, post-cardiopulmonary bypass vasoplegia). * Severe missing data.

Treatments Being Tested

OTHER

Vasopressor Exposure Levels

This is an observational study with no active intervention. The study evaluates the association between natural variations in vasopressor exposure levels (measured by Vasoactive-Inotropic Score, VIS) and clinical outcomes in patients receiving VA-ECMO for cardiogenic shock.

Locations (1)

Beijing Anzhen Hospital
Beijing, Beijing Municipality, China