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RECRUITINGOBSERVATIONAL

Impact of Stress on Cardiovascular Events in Patients with Peripheral Arterial Disease

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality worldwide. Patients with peripheral arterial disease are at increased risk suffering from major adverse cardiac and limb events. Acute and chronic stress affect the cardiovascular system. Long-term negative stressors lead to cardiovascular diseases and can aggravate already existing cardiovascular diseases. However, current guidelines on cardiovascular disease prevention highlight stress as a cardiovascular risk factor there is a lack of consensus about the definition and measurement of stress. The aim of the proposed trial is to evaluate different stress measuring methods in patients with PAD depending on the occurrence of cardiovascular events.

Who May Be Eligible (Plain English)

Who May Qualify: Diagnosis of lower extremity PAD based on: - Limb bypass surgery or - aorta-femoral bypass surgery or - percutaneous transluminal angioplasty revascularization of the iliac or infrainguinal arteries or - limb or foot amputation for arterial vascular disease or - intermittent claudication and one or more of either an ankle brachial index (ABI) of less than 0.90 or a peripheral artery stenosis (≥50%) documented by angiography or duplex ultrasound or carotid revascularization or asymptomatic carotid artery stenosis of at least 50% diagnosed by duplex ultrasound or angiography Who Should NOT Join This Trial: - atrial fibrillation - high premature ventricular contractions burden - pacemaker with constant ventricular pacing - antiarrhythmic drugs class I or III Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: Diagnosis of lower extremity PAD based on: * Limb bypass surgery or * aorta-femoral bypass surgery or * percutaneous transluminal angioplasty revascularization of the iliac or infrainguinal arteries or * limb or foot amputation for arterial vascular disease or * intermittent claudication and one or more of either an ankle brachial index (ABI) of less than 0.90 or a peripheral artery stenosis (≥50%) documented by angiography or duplex ultrasound or carotid revascularization or asymptomatic carotid artery stenosis of at least 50% diagnosed by duplex ultrasound or angiography Exclusion Criteria: * atrial fibrillation * high premature ventricular contractions burden * pacemaker with constant ventricular pacing * antiarrhythmic drugs class I or III

Locations (1)

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen
Essen, Germany