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RECRUITINGINTERVENTIONAL

Low Level Light Therapy & Skin Pigmentation

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this clinical trial is to determine if there is a difference in eyelid temperature after low-level light therapy (LLLT) in individuals with different amounts of skin pigmentation and dry eye/meibomian gland disease. Participants will have 3 fifteen minute in office LLLT therapy sessions over a period of approximately 7 to 14 days.

Who May Be Eligible (Plain English)

Who May Qualify: - Ability to read and understand the study willing to sign a consent form in English - Age 18 years or older at enrollment - Individuals with MGD based on one or more of the following clinical signs/symptoms, e.g., meibum quality score of 1-3 (Bron et al.), meibography score of 1, 2, or 3 on the Pult Meiboscale, non-invasive 1st tear break up time of 10 seconds or less, or an Ocular Surface Disease Index (OSDI) score greater than 12 points. Who Should NOT Join This Trial: - Active anterior segment pathology (e.g., bacterial conjunctivitis, microbial keratitis) - History of systemic disease associated with aqueous-deficient dry eye disease (e.g., Sjogren's syndrome) - History of corneal surgery, refractive surgery, or eyelid surgery within 6 months - History of corneal ectasia (e.g. keratoconus, Pellucid marginal degeneration) - History of ocular trauma within 6 months - History of LipiFlow, iLux, Meiboflow, IPL or LLLT within the last 12 months - Habitual use of photosensitizing medications within the last 30 days - Pregnant and/or lactating females, by self-report - Pigmented lesions, tattoos, or skin cancer in the periocular region - Unwilling to have eyes photographed or video recorded Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Ability to read and understand the study informed consent in English * Age 18 years or older at enrollment * Individuals with MGD based on one or more of the following clinical signs/symptoms, e.g., meibum quality score of 1-3 (Bron et al.), meibography score of 1, 2, or 3 on the Pult Meiboscale, non-invasive 1st tear break up time of 10 seconds or less, or an Ocular Surface Disease Index (OSDI) score greater than 12 points. Exclusion Criteria: * Active anterior segment pathology (e.g., bacterial conjunctivitis, microbial keratitis) * History of systemic disease associated with aqueous-deficient dry eye disease (e.g., Sjogren's syndrome) * History of corneal surgery, refractive surgery, or eyelid surgery within 6 months * History of corneal ectasia (e.g. keratoconus, Pellucid marginal degeneration) * History of ocular trauma within 6 months * History of LipiFlow, iLux, Meiboflow, IPL or LLLT within the last 12 months * Habitual use of photosensitizing medications within the last 30 days * Pregnant and/or lactating females, by self-report * Pigmented lesions, tattoos, or skin cancer in the periocular region * Unwilling to have eyes photographed or video recorded

Treatments Being Tested

DEVICE

Three 15-minute low-level light therapy sessions using Light Emitting Diodes of wavelength 633nm (Essilor epi-c plus).

A mask with Light Emitting Diodes wavelength 633nm will be placed over closed eyes for 15 minutes.

Locations (1)

The University of Houston College of Optometry
Houston, Texas, United States