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RECRUITINGINTERVENTIONAL

Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or poor-quality sleep. This prospective, randomized, case-crossover study aims to examine the acute effects of sleep disruption on clinically relevant cardiac ectopy pertinent to AF.

Who May Be Eligible (Plain English)

Who May Qualify: - Are age 21 years or older - Have a HGNS device implanted for obstructive sleep apnea and followed up at UCSF Health - Are willing to abstain from using the upper airway stimulation device for no more than two consecutive days as instructed over the 14-day trial period - Able and willing to provide written willing to sign a consent form Who Should NOT Join This Trial: - Currently pregnant or trying to get pregnant - Are currently taking class 1 or 3 anti-arrhythmic medications - Have a history of permanent AF or expected to have continuous AF throughout the study period - Have congenital heart disease - Ventricular pacing \>40% - Are unable to read or sign to provide willing to sign a consent form Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Are age 21 years or older * Have a HGNS device implanted for obstructive sleep apnea and followed up at UCSF Health * Are willing to abstain from using the upper airway stimulation device for no more than two consecutive days as instructed over the 14-day trial period * Able and willing to provide written informed consent Exclusion Criteria: * Currently pregnant or trying to get pregnant * Are currently taking class 1 or 3 anti-arrhythmic medications * Have a history of permanent AF or expected to have continuous AF throughout the study period * Have congenital heart disease * Ventricular pacing \>40% * Are unable to read or sign to provide informed consent

Treatments Being Tested

DEVICE

HGNS Use Randomized Instructions

In this intervention assignment, participants will be instructed to turn off/not use their HGNS device during that night of sleep. HGNS 'on': In this intervention assignment, participants will be instructed to turn on/use their HGNS device during that night of sleep.

Locations (1)

UCSF Medical Center at Parnassus
San Francisco, California, United States